Dra. Isabel Quijada Garrido Científica Titular



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Dra. Isabel Quijada Garrido
Científica Titular

Departamento de Química Física de Polímeros

Instituto de Ciencia y Tecnología de Polímeros

C/Juan de la Cierva 3, Madrid 28006, España


Tel.: +34-91-5622900 ext 254

Fax: +34-91-5644853

E-mail:iquijada@ictp.csic.es

Isabel Quijada es Científica Titular (2007) en el Instituto de Ciencia y Tecnología de Polímeros (ICTP) del Consejo Superior de Investigaciones (CSIC) en Madrid. Desde enero de 2011 es Vicedirectora Científica del ICTP. Obtuvo el grado de doctor (1996) en la Universidad Complutense de Madrid por su trabajo realizado en el ICTP sobre la difusión de aditivos en polipropileno y nylon 12 y el estudio de sus mezclas. Después de su Tesis doctoral, realizó una estancia postdoctoral en el Instituto Max Planck para la Investigación de Polímeros de Mainz (Alemania) bajo la supervisión del Dr. Hans W. Spiess y el Dr. Manfred Wilhelm. Posteriormente estuvo dos años (1997-1999) en el Instituto de Química Macromolecular de Friburgo (Alemania) trabajando en el grupo de la Dra. Claudia Schmidt. Durante su período postdoctoral en Friburgo, estuvo dedicada al estudio del comportamiento reológico de cristales líquidos poliméricos de cadena lateral termotrópicos y disoluciones de surfactantes liotrópicos. Desde el 2007 forma parte de la plantilla del CSIC como Científica Titular.

Su grupo de investigación trabaja en el desarrollo de sistemas sensibles a estímulos como la temperatura, pH y luz, así como en el desarrollo de sistemas inteligentes con biodegradabilidad. Explotando técnicas avanzadas como la MRI (imagen por resonancia magnética) han investigado la cinética de hinchamiento y el estudio de la difusión de fármacos y sustancias activas en función de estímulos. Sustratos biocompatibles basados en polihidroxialcanoatos se han modificado para el crecimiento celular y la regeneración de diversos tejidos (urotelial, óseo, tejido nervioso). También se han desarrollado metodologías para la modificación superficial de diferentes materiales con polímeros sensibles a estímulos para controlar la adhesión de películas celulares en función de la temperatura y en terapias de mínima invasión. Actualmente, están trabajando en la integración de los polímeros sensibles al pH y temperaturas con materiales micro y nano-estructurados.


Listado de Publicaciones:[1-51]

[1] J.M. García-García, I. Quijada-Garrido, L. López, R. París, M.T. Núñez-López, E. De La Peña Zarzuelo, L. Garrido, The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells, Materials Science and Engineering C, 33 (2013) 362-369.

[2] I. Mora-Barrantes, J.L. Valentín, A. Rodríguez, I. Quijada-Garrido, R. Paris, Poly(styrene)/silica hybrid nanoparticles prepared via ATRP as high-quality fillers in elastomeric composites, Journal of Materials Chemistry, 22 (2012) 1403-1410.

[3] J.M. García-García, L. López, R. París, M.T. Núñez-López, I. Quijada-Garrido, E. De La Peña Zarzuelo, L. Garrido, Surface modification of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer films for promoting interaction with bladder urothelial cells, Journal of Biomedical Materials Research - Part A, 100 A (2012) 7-17.

[4] J.M. García-García, L. Garrido, I. Quijada-Garrido, J. Kaschta, D.W. Schubert, A.R. Boccaccini, Novel poly(hydroxyalkanoates)-based composites containing Bioglass® and calcium sulfate for bone tissue engineering, Biomedical Materials (Bristol), 7 (2012).

[5] C. García-Aparicio, I. Quijada-Garrido, L. Garrido, Diffusion of small molecules in a chitosan/water gel determined by proton localized NMR spectroscopy, Journal of Colloid and Interface Science, 368 (2012) 14-20.

[6] R. París, I. Quijada-Garrido, O. García, M. Liras, BODIPY-conjugated thermo-sensitive fluorescent polymers based on 2-(2-methoxyethoxy)ethyl methacrylate, Macromolecules, 44 (2011) 80-86.

[7] R. París, I. Quijada-Garrido, Synthesis and aggregation properties in water solution of comblike methacrylic polymers with oligo(propylene glycol)-block-oligo(ethylene glycol) as side chains, Journal of Polymer Science, Part A: Polymer Chemistry, 49 (2011) 1928-1932.

[8] R. París, M. Liras, I. Quijada-Garrido, Thermoresponsive behavior of mixtures of epoxy functionalized oligo(ethylene glycol) methacrylate copolymers, Macromolecular Chemistry and Physics, 212 (2011) 1859-1868.

[9] R. París, J. García, I. Quijada-Garrido, Thermo- and pH-sensitive hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate and methacrylic acid, Polymer International, 60 (2011) 178-185.

[10] S. Medel, J. Manuel García, L. Garrido, I. Quijada-Garrido, R. París, Thermo- and pH-responsive gradient and block copolymers based on 2-(2-methoxyethoxy)ethyl methacrylate synthesized via atom transfer radical polymerization and the formation of thermoresponsive surfaces, Journal of Polymer Science, Part A: Polymer Chemistry, 49 (2011) 690-700.

[11] M. Liras, J.M. García-García, I. Quijada-Garrido, A. Gallardo, R. París, Thermo-responsive allyl-functionalized 2-(2-methoxyethoxy)ethyl methacrylate-based polymers as versatile precursors for smart polymer conjugates and conetworks, Macromolecules, 44 (2011) 3739-3745.

[12] M. Liras, O. García, I. Quijada-Garrido, R. París, Transformation of the bromine end group into thiol in (Meth)acrylic polymers synthesized by atom transfer radical polymerization, Macromolecules, 44 (2011) 1335-1339.

[13] J.M. García-García, M. Liras, I. Quijada-Garrido, A. Gallardo, R. París, Swelling control in thermo-responsive hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate by crosslinking and copolymerization with N-isopropylacrylamide, Polymer Journal, 43 (2011) 887-892.

[14] J.M.B. De Ojeda, I. Quijada-Garrido, J.M. Barrales-Rienda, Synthesis, characterization and properties of N-maleimide side-chain liquid crystalline copolymers, Journal of Polymer Science, Part A: Polymer Chemistry, 49 (2011) 495-510.

[15] M.M. Bernal, M. Liras, R. Verdejo, M.A. López-Manchado, I. Quijada-Garrido, R. París, Modification of carbon nanotubes with well-controlled fluorescent styrene-based polymers using the Diels-Alder reaction, Polymer, 52 (2011) 5739-5745.

[16] R. París, I. Quijada-Garrido, Temperature- and pH-responsive behaviour of poly(2-(2-methoxyethoxy)ethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) hydrogels, European Polymer Journal, 46 (2010) 2156-2163.

[17] R. París, J.M. García, I. Quijada-Garrido, Synthesis and characterization of a new acrylic polymeric ibuprofen prodrug, Journal of Applied Polymer Science, 117 (2010) 3271-3276.

[18] G. Frutos, A. Prior-Cabanillas, R. París, I. Quijada-Garrido, A novel controlled drug delivery system based on pH-responsive hydrogels included in soft gelatin capsules, Acta Biomaterialia, 6 (2010) 4650-4656.

[19] I. Quijada-Garrido, A. Prior-Cabanillas, R. Paris, G. Frutos, J.M. Barrales-Rienda, Water transport properties of pH-responsive hydrogels based on poly(methacrylic acid) with polyether side chains by magnetic resonance imaging, Macromolecular Chemistry and Physics, 210 (2009) 520-530.

[20] R. París, I. Quijada-Garrido, Swelling and hydrolytic degradation behaviour of pH-responsive hydrogels of poly[(N-isopropylacrylamide)-co-(methacrylicacid)] crosslinked by biodegradable polycaprolactone chains, Polymer International, 58 (2009) 362-367.

[21] R. París, I. Quijada-Garrido, Swelling behaviour of thermo-sensitive hydrogels based on oligo(ethylene glycol) methacrylates, European Polymer Journal, 45 (2009) 3418-3425.

[22] R. París, J.M. Barrales-Rienda, I. Quijada-Garrido, Dynamic swelling of hydrogels based on random terpolymers of N-isopropylacrylamide, methacrylic acid and poly(ethylene glycol) macromonomer, Polymer, 50 (2009) 2065-2074.

[23] H. Siebert, I. Quijada-Garrido, J. Vermant, L. Noirez, W.R. Burghardt, C. Schmidt, Director orientation of nematic side-chain liquid crystalline polymers under shear flow: Comparison of a flow-aligning and a non-flow-aligning polysiloxane, Macromolecular Chemistry and Physics, 208 (2007) 2161-2172.

[24] I. Quijada-Garrido, V. Iglesias-González, J.M. Mazón-Arechederra, J.M. Barrales-Rienda, The role played by the interactions of small molecules with chitosan and their transition temperatures. Glass-forming liquids: 1,2,3-Propantriol (glycerol), Carbohydrate Polymers, 68 (2007) 173-186.

[25] A. Prior-Cabanillas, J.M. Barrales-Rienda, G. Frutos, I. Quijada-Garrido, Swelling behaviour of hydrogels from methacrylic acid and poly(ethylene glycol) side chains by magnetic resonance imaging, Polymer International, 56 (2007) 506-511.

[26] I. Quijada-Garrido, B. Laterza, J.M. Mazón-Arechederra, J.M. Barrales-Rienda, Characteristic features of chitosan/glycerol blends dynamics, Macromolecular Chemistry and Physics, 207 (2006) 1742-1751.

[27] R.G. Sousa, A. Prior-Cabanillas, I. Quijada-Garrido, J.M. Barrales-Rienda, Dependence of copolymer composition, swelling history, and drug concentration on the loading of diltiazem hydrochloride (DIL.HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its release behaviour from hydrogel slabs, Journal of Controlled Release, 102 (2005) 595-606.

[28] I. Quijada-Garrido, A. Prior-Cabanillas, L. Garrido, J.M. Barrales-Rienda, Swelling monitorization of poly[(N-isopropylacrylamide)-co-(methacrylic acid)] copolymers by magnetic resonance imaging, Macromolecules, 38 (2005) 7434-7442.

[29] A. Prior-Cabanillas, I. Quijada-Garrido, G. Frutos, J.M. Barrales-Rienda, Influence of the swelling history on the swelling kinetics of stimuli-responsive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels, Polymer, 46 (2005) 685-693.

[30] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, I. Schnell, H.W. Spiess, Advanced 1H solid-state NMR spectroscopy on hydrogels, 1: The effect of hydrogen bonding in the collapse of poly(methacrylic acid) (PMAA) hydrogels, Macromolecular Chemistry and Physics, 205 (2004) 430-437.

[31] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, I. Schnell, H.W. Spiess, Advanced 1H solid-state NMR spectroscopy on hydrogels, 2 a: The formation of hydrogen bonds in hydrogels based on N-isopropylacrylamide (NiPAAm) and methacrylic acid (MAA), Macromolecular Chemistry and Physics, 205 (2004) 438-447.

[32] E. Díez-Peña, P. Frutos, G. Frutos, I. Quijada-Garrido, J.M. Barrales-Rienda, The influence of the copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels, AAPS PharmSciTech [electronic resource]. 5 (2004).

[33] E. Díez-Peña, P. Frutos, G. Frutos, I. Quijada-Garrido, J.M. Barrales-Rienda, The influence of the copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(N-isopropycrylamide)-co-(meth-acrylic acid) hydrogels, AAPS PharmSciTech, 5 (2004).

[34] E. Díez-Pena, I. Quijada-Garrido, P. Frutos, J.M. Barrales-Rienda, Analysis of the swelling dynamics of crosslinked P(N-iPAAm-co-MAA) copolymers, the corresponding homopolymers and their interpenetrating networks. Kinetics of water penetration into the gel above the pKa of MAA comonomeric units, Polymer International, 52 (2003) 956-965.

[35] E. Díez-Peńa, I. Quijada-Garrido, J.M. Barrales-Rienda, Analysis of the swelling dynamics of cross-linked P(N-iPAAm-co-MAA) copolymers and their homopolymers under acidic medium. A kinetics interpretation of the overshooting effect, Macromolecules, 36 (2003) 2475-2483.

[36] H. Siebert, P. Becker, I. Quijada-Garrido, D.A. Grabowski, C. Schmidt, In situ deuteron NMR investigations of sheared liquid crystalline polymers, Solid State Nuclear Magnetic Resonance, 22 (2002) 311-326.

[37] E. Díez-Peña, I. Quijada-Garrido, P. Frutos, J.M. Barrales-Rienda, Thermal properties of cross-linked poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], their random copolymers [P(N-iPAAm-co-MAA)], and sequential interpenetrating polymer networks (IPNs), Macromolecules, 35 (2002) 2667-2675.

[38] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, M. Wilhelm, H.W. Spiess, NMR studies of the structure and dynamics of polymer gels based on N-isopropylacrylamide (NiPAAm) and methacrylic acid (MAA), Macromolecular Chemistry and Physics, 203 (2002) 491-502.

[39] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, On the water swelling behaviour of poly(N-isopropylacrylamide) [P(N-iPAAam)], poly(methacrylic acid) [P(MAA)], their random copolymers and sequential interpenetrating polymer networks (IPNs), Polymer, 43 (2002) 4341-4348.

[40] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, Hydrogen-bonding effects on the dynamic swelling of P(N-iPAAm-co-MAA) copolymers. A case of autocatalytic swelling kinetics, Macromolecules, 35 (2002) 8882-8888.

[41] E. Díez-Peña, I. Quijada-Garrido, J.M. Barrales-Rienda, Hydrogels based on N-isopropylacrylamide and methacrylic acid: Thermal stability and glass transition behaviour, Polymer Bulletin, 48 (2002) 83-91.

[42] S.E. Cramer, I. Quijada-Garrido, R. Ulrich, J.M. Barrales-Rienda, H.W. Spiess, Dynamic mechanical and dielectric properties of ORMOCER® incorporating functionalized poly(styrene) latexes, Journal of Polymer Science, Part B: Polymer Physics, 39 (2001) 860-867.

[43] I. Quijada-Garrido, H. Siebert, C. Friedrich, C. Schmidt, Flow behavior of two side-chain liquid crystal polymers studied by transient rheology, Macromolecules, 33 (2000) 3844-3854.

[44] I. Quijada-Garrido, M. Fernández De Velasco-Ruiz, J.M. Barrales-Rienda, Fickian diffusion of erucamide (13-cis-docosenamide) in poly(laurolactam) (Nylon 12) (PA-12), Macromolecular Chemistry and Physics, 201 (2000) 375-381.

[45] M. Fernández De Velasco-Ruiz, I. Quijada-Garrido, R. Benavente, J.M. Barrales-Rienda, Miscibility studies of erucamide (13-cis-docosenamide)/poly(laurolactam) (nylon 12) (PA-12) blends, Polymer, 41 (2000) 5819-5828.

[46] I. Quijada-Garrido, H. Siebert, P. Becker, C. Friedrich, C. Schmidt, Transient rheological behavior of tumbling side-chain liquid crystal polymers and determination of their λ parameters, Rheologica Acta, 38 (1999) 495-502.

[47] I. Quijada-Garrido, M. Wilhelm, H.W. Spiess, J.M. Barrales-Rienda, Solid-state NMR studies of structure and dynamics of erucamide/ isotactic poly(propylene) blends, Macromolecular Chemistry and Physics, 199 (1998) 985-995.

[48] I. Quijada-Garrido, J.M. Barrales-Rienda, J.M. Pereña, G. Frutos, Dynamic mechanical and dielectric behavior of erucamide (13-Cis-Docosenamide), isotactic poly(propylene), and their blends, Journal of Polymer Science, Part B: Polymer Physics, 35 (1997) 1473-1482.

[49] I. Quijada-Garrido, J.M. Barrales-Rienda, J.M. Pereña, G. Frutos, Solubility of erucamide (13-cis-docosenamide) in isotactic poly(propylene) and thermal behaviour of their blends, Polymer, 38 (1997) 5125-5135.



[50] I. Quijada-Garrido, J.M. Barrales-Rienda, G. Frutos, Diffusion of erucamide (13-cis-docosenamide) in isotactic polypropylene, Macromolecules, 29 (1996) 7164-7176.

[51] I. Quijada-Garrido, Desorption of erucamide vapor in vacuum from erucamide/isotactic polypropylene films, Macromolecules, 29 (1996) 8791-8797.


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