Sixth international symposium on stem cell therapy and applied cardiovascular biotechnology



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SIXTH INTERNATIONAL SYMPOSIUM

ON STEM CELL THERAPY

AND APPLIED CARDIOVASCULAR BIOTECHNOLOGY”
Madrid (Spain), 23RD AND 24TH APRIL 2009


Auditorio

Consejo Superior de Investigaciones Científicas (CSIC)

C/ Serrano 117

28006 Madrid



  1. ACCREDITATION




  1. ORGANIZATION




      • Direction

      • International Scientific Advisory Board

      • Executive Local Committee

      • Organization




  1. EDUCATIONAL OBJECTIVES




  1. FACULTY




  1. SCIENTIFIC AGENDA




  1. GENERAL INFORMATION




  • Meeting Venue

  • Date

  • Official languages

  • Technical Secretariat




  1. WEBSITE AND EDUCATIONAL PRODUCTS


8. COLLABORATION AND SPONSORS

1. ACCREDITATION


  • Spanish Society of Cardiology. Continuing Medical Education Accreditation Program.




  • EBAC (European Board for Accreditation in Cardiology) 9 CME credits




  • Agencia Laín Entralgo (Consejería de Sanidad, Comunidad de Madrid)


2. DIRECTION

DIRECTION

Francisco Fernández-Avilés

Servicio de Cardiología


Hospital General Universitario Gregorio Marañón (Madrid, Spain)
CO-DIRECTION
Mª Eugenia Fernandez Santos

Unidad de Producción Celular

Hospital General Universitario Gregorio Marañón (Madrid, Spain)
Bernard Gersh

Mayo Clinic (Rochester, USA)


John F. Martin

Centre for Cardiovascular Biology & Medicine (London, United Kingdom)



José Alberto San Román

Instituto de Ciencias del Corazón (ICICOR)

Hospital Clínico-Universitario de Valladolid (Valladolid, Spain)



Ana Sanchez

Instituto de Biología y Genética Molecular IBGM


Facultad de Medicina. Universidad de Valladolid (Valladolid, Spain)

Pedro L. Sánchez

Servicio de Cardiología


Hospital General Universitario Gregorio Marañón (Madrid, Spain)
James T. Willerson

Texas Heart Institute (Houston, USA)




TECHNICAL DIRECTION


Ana Fernández - Baza

Servicio de Cardiología

Hospital General Universitario Gregorio Marañón (Madrid, Spain)


INTERNATIONAL SCIENTIFIC ADVISORY BOARD


Jozef Bartunek (Aalst, Belgium)

Nabil Dib (San Diego, USA)

Stefanie Dimmeler (Frankfurt, Germany)

Helmut Drexler (Hannover, Germany)

Valentín Fuster (New York, USA)

Manuel Galiñanes (Leicester, United Kingdom)

Javier García-Sancho (Valladolid, Spain)

Bernard Gersh (Rochester, USA)

Juan Carlos Izpisúa (La Jolla, USA)

Stefan Janssens (Leuven, Belgium)

Anthony Mathur (London, United Kingdom)

John Martin (Londres, United Kigdom)

Philippe Menasche (Paris, France)

Bernardo Nadal-Ginard (Boston, USA)

Emerson Perin (Houston, USA)

Warren Sherman (New York, USA)

Dorys Taylor (Minneapolis,USA)

William Wijns (Aalst, Belgium)

James T. Willerson (Houston, USA)

Andreas Zeiher (Frankfurt, Germany)
EXECUTIVE LOCAL COMMITTEE

Marta Alhama (Hospital G. Univ Gregorio Marañon, Madrid)

Felipe Atienza (Hospital G. Univ Gregorio Marañon, Madrid)

Javier Bermejo (Hospital G. Univ Gregorio Marañon, Madrid)

Marta Dominguez (Hospital G. Univ Gregorio Marañon, Madrid)

Lucia Fernandez Peña (Hospital G. Univ Gregorio Marañon, Madrid)

Jaime Elizaga (Hospital G. Univ Gregorio Marañon, Madrid)

Pilar Garabato (Hospital G. Univ Gregorio Marañon, Madrid)

Enrique Gutierrez (Hospital G. Univ Gregorio Marañon, Madrid)

Ricardo Sanz (Hospital G. Univ Gregorio Marañon, Madrid)

Adolfo Villa (Hospital G. Univ Gregorio Marañon, Madrid)

ORGANIZATION




  • Servicio de Cardiología. Hospital General Universitario Gregorio Marañón

  • Instituto de Ciencias del Corazón (ICICOR) del Hospital Clínico-Universitario de Valladolid

  • Red Temática de Investigación Cardiovascular del Instituto de Salud Carlos III (RECAVA)

  • Red Temática de Terapia Celular del Instituto de Salud Carlos III (TERCEL)

  • Grupo de Terapia Celular Aplicada al Miocardio (TECAM, Hospital Clínico-Universitario de Valladolid, Hospital Universitario Río Hortega, Instituto de Biología y Genética Molecular)

  • Task Force on Stem Cell Regeneration of the Heart (European Society of Cardiology)


3. EDUCATIONAL OBJECTIVES
This symposium is aimed at both medical and non-medical scientists interested in the study and application of stem cell therapy and other biotechnological advances for the prevention and treatment of cardiovascular failure. For this reason the audience comprises:


  1. Preclinical researchers from all areas wishing to deepen their knowledge of cardiovascular biotechnological developments with therapeutic potential.




  1. Doctors specialising in the care of patients suffering from cardiovascular diseases, and who are interested in finding out about and discussing the current state of affairs and the future prospects for the application of these new therapeutic methods.




  1. Doctors involved n interventions dedicated to cardiovascular pathology and who are interested in the results and perspectives of gene vehiculization techniques, the stimulation of endogenous progenitors, cell transplant or electromechanical helps to the cardiovascular system to fight cardiovascular disease.




  1. Medical or no medical professionals interested in the development of units and networks aimed at the translation of cardiovascular knowledge from bench to bedside and vice versa.




  1. Medical or no medical professionals interested in envisaging the opportunities for competition of biotechnology in the cardiovascular field

At the end of the conference those present will have acquired the following skills:




  1. Knowledge and ability to discuss the latest advances in the role of progenitor cells in the integrity of the cardiovascular system of a healthy individual.




  1. Knowledge and ability to discuss the latest experimental advances in the renewal and repair capacity of the damaged cardiovascular structure via the transplant of adult or embryonic stem cells, the stimulation of endogenous progenitors, .




  1. Know about and be able to objectively debate the current state of feasibility, safety and efficacy with regards to the clinical application of cell therapy and other new biotechnological treatments.




  1. Knowledge and ability to debate objectively on the efficiency of these types of treatment in patients with acute or chronic cardiovascular diseases which.




  1. Ability to predict the future and the possibilities of scientific and professional attitude with regard to offering these therapeutic methods.




  1. Ability to evaluate and decide one’s own ability to participate in the application of these therapies for healthcare, clinical, and preclinical purposes.




  1. Ability to identify those institutions and groups with the highest performance capabilities in these fields, and be able to establish contacts for educational, scientific, and healthcare purposes.


4. FACULTY

Joseph Bartunek (Aalst, Belgium)

Natividad Calvente (Madrid, Spain)

Alain Carpentier (Paris, France)

Dominique Charron (Paris, France)

Juan Carlos Chachques (Paris, France)

Emanuelle Cozzi (Padova, Italy)

Nabil Dib (San Diego, USA)

Stefanie Dimmeler (Frankfurt, Germany)

Arturo Fernandez-Cruz (Madrid, Spain)

O. Howard Frazier (Houston, USA)

Valentín Fuster (New York, USA)

Manuel Galiñanes (Leicester, UK)

David García-Dorado (Barcelona, Spain)

Bernard Gersh (Rochester, USA)

Angel González Pinto (Madrid, Spain)

Enrique Gutierrez (Madrid, Spain)

Jose Lasso (Madrid, Spain)

Jonathan Hill (London, United Kingdom)

Juan Carlos Izpisúa (La Jolla, USA)

Stefan Janssens (Leuven, Belgium)

Dara Kraitchman (Baltimore, USA)

John Martin (London, United Kingdom)

Rafael Matesanz (Madrid, Spain)

Philippe Menasche (Paris, France)

Bernardo Nadal-Ginard (Boston, USA)

Mark S. Penn (Cleveland, Ohio)

Rosa Perez-Cano (Madrid, Spain)

Emerson Perin (Houston, USA)

Felipe Prosper (Pamplona, Spain)

Eduardo Punset (Madrid, Spain)

Alberto San Román (Valladolid, Spain)

Ricardo Sanz (Madrid, Spain)

Robert Simari (Rochester, USA)

José Suárez de Lezo (Cordoba, Spain)

Doris Taylor (Minneapolis,USA)

André Terzic (Rochester, USA)

William Wijns (Aalst, Belgium)

James T. Willerson (Houston, USA)

Kai C. Wollert (Hannover, Germany)

Magdi Yacoub (Harefield, United Kingdom)

Andreas Zeiher (Frankfurt, Germany)




5. SCIENTIFIC AGENDA

THURSDAY, 23RD APRIL 2009
(7:45-8:30)

REGISTRATION
(8:30-9:00)
WELCOMING

(9:00-10:30)

OPENING SPECIAL LECTURES
Chairs: David García-Dorado (Barcelona, Spain)

Manuel Galiñanes (Leicester, UK)

(9:00-9:25) Biotechnological therapies for heart dysfunctions:

from valves to total heart replacement

Alain Carpentier (Paris, France)


(9:30-9:55) Genes for cell reprogramming. Is this the next bridge?

Valentin Fuster (New York, USA)


(10.00-10:25) New consensus on stem cell therapy for heart repair

John Martin (London, UK)




10.30 - 11.00 Coffee break
(11.00 - 13.45)
WHAT’S NEW?

Chairs: José Suarez de Lezo (Cordoba, Spain)

Joseph Bartunek (Aalst, Belgium)


(11.00 – 11.20) On embryonic and embryonic-like cells?

André Terzic (Rochester, USA)


(11.20 – 11.40) On classical and new adult cells?

Mark S. Penn (Cleveland, USA)


(11.40 – 12.00) On heart tissue reengineering?

Juan Carlos Chachques (Paris, France)


(12.00 – 12.20) On delivering and navigation?

Emerson Perin (Houston, USA)


(12.20 – 12.40) On clinical trials?

Kai C. Wollert (Hannover, Germany)


(12.40 – 13.00) On imaging?

Jonathan Hill (London, United Kingdom)


(13.00 – 13.20) On new organizational models for optimal cell processing
and application?

Robert Simari (Rochester, USA)


(13.20 – 13.40) On regulatory?

Natividad Calvente (Madrid, Spain)


13.45 – 15.30 Lunch and Poster Exhibition

SALON DE ACTOS. RESIDENCIA DE ESTUDIANTES CSIC


Chairs: Philippe Menasche (Paris, France)

Stefan Janssens (Leuven, Belgium)

Felipe Prosper (Pamplona, Spain)

In this “Poster Exhibition” research teams involved in the topic of the Symposium will have the opportunity of presenting selected parts of their work to the audience


An external Review Committee will select those submitted works suitable for the session, which will be presented and discussed with three moderators in front of an appreciative audience.
The authors of the three best posters of the session, according to the Review Committee judgement, will be invited to present their work in the opening session the following day (24th April 2009) in an oral presentation format (slides), and will receive the Moderated Poster Awards (2000 € each)

(15.30- 17:30)



SPECIAL THEMED SESSION: “NEW HEARTS FOR OLD AND NEW NEEDS”
Chairs: Angel González-Pinto (Madrid, Spain)

Rafael Matesanz (Madrid, Spain)

(15.30-15.50) Cardiac replacement for end-stage heart disease: need, demand, supply and dreams

Magdi Yacoub (London, UK)




        1. Bridge? Destination? Both? New paradigms in mechanical heart replacement

O. Howard Frazier (Houston, USA)
(16.10 – 16.30) The Carpentier Heart: from missile technology to intelligent total heart replacement

Alain Carpentier (Paris, France)


(16.30 – 16.50) Xenotransplant. Still a hope?

Emanuele Cozzi (Padova, Italy)


(16.50 – 17.10) Stem cell-based heart replacement: the Taylor Heart

Doris Taylor (Minneapolis, USA)




FRIDAY, 24th APRIL 2009

AUDITORIUM
(9:00 - 10:00)

BEST POSTERS PRESENTATION
Chairs: Philippe Menasché (Paris, France)

Stefanie Dimmeler (Frankfurt, Germany)


(9:00-9.15) Prizes-giving
(9:15-9:30) Winner work presentation and discussion
(9:30-9:45) Winner work presentation and discussion
(9:45-10:00) Winner work presentation and discussion

(10:00 – 11:30)



CONTROVERSIES
Chairs: Bernardo Nadal-Ginard (Boston, USA)

Arturo Fernandez-Cruz (Madrid, Spain)


(10.00 – 10.45)

Stem cell therapy treatment in AMI after meta-analysis results?
10.00 Pro Andreas Zeiher (Frankfurt, Germany)

10.15 Contra Bernard Gersh (Rochester, USA)

Rebuttal

10.30 Pro Andreas Zeiher (Frankfurt, Germany)

10.35 Contra Bernard Gersh (Rochester, USA)

10.40 Conclusion

(10.45 – 11.30)

Is it time to use allogenic stem cells?
10.45 Pro Mark S. Penn (Cleveland, USA)

11.00 Contra Dominique Charron (Paris, France)

Rebuttal

11.15 Pro Mark S. Penn (Cleveland, USA)

11.20 Contra Dominique Charron (Paris France)

11.25 Conclusion




11.30 – 12.00 Coffee Break
(12.00 – 13.30)

I HAVE A QUESTION FOR YOU, DR. EXPERT*
Chairs: Eduardo Punset (Barcelona, Spain)

John Martin (London, UK)

*During this special session six experts in the field will answer direct or video-submitted questions by scientists key opinion leaders, politicians, journalists, and patient. Questions will be organized in three topic blocks: bench (mechanism of action, type of cells, homing and tracking, etc); bedside (safety, efficacy, clinical scenarios, delivery), and organization-regulatory-funding.

EXPERTS AT THE STAGE PANEL
James T. Willerson (Houston, USA)

Bernardo Nadal-Ginard (Boston, USA)

Stefanie Dimmeler (Frankfurt, Germany)

Joseph Bartunek (Aalst, Belgium)

Dara Kraitchman (Baltimore, USA)

Philippe Menasché (Paris, France)



EXPERTS AT THE FRONT ROW PANEL
The front row panel will be formed by the entire faculty involved in the meeting plus politicians, journalists, patients and all the audience present in the auditorium
(13.30 – 14.00)

LIVE CASE RETRANSMISSION
Chairs (Auditorium): Nabil Dib (San Diego, USA)

Andreas Zeiher (Frankfurt, Germany)

José Lasso (Madrid, Spain)
Operators (Cath-Lab, Hospital General Universitario Gregorio Marañón):
Emerson Perin (Houston, USA)

Ricardo Sanz (Madrid, Spain)

Enrique Gutierrez (Madrid, Spain)

Rosa Perez Cano (Madrid, Spain)

(14.00 – 15.30)

CLOSING SESSION: “NEXT STEPS IN HEART REPLACEMENT”
Chairs: James T. Willerson (Houston, USA)

Alberto San Roman (Valladolid, Spain)


(14.00 – 14.20) My fundamental view

Juan Carlos Izpisúa (La Jolla, USA)


(14.20 – 14.40) My translational view

Philippe Menasché (Paris, France)


(14.40 – 15:00) My clinical view

William Wijns (Aalst, Belgium)


(15:00 – 15.20) My global view

Magdi Yacoub (Harefield, UK)


(15.20) ADJOURN

Francisco Fernandez-Aviles (Madrid, Spain)




6. GENERAL INFORMATION
Meeting Venue

Auditorium Consejo Superior de Investigaciones Científicas (CSIC)

C/ Serrano 117

28006 Madrid



Date

23rd and 24th April 2009
Official Languages

English and Spanish (simultaneous translation will be available)

Technical Secretariat

Viajes Orbiazul

C/Alonso Pesquera 2

47002 Valladolid

tf. 00 34 983 30 91 22

fx. 00 34 983 29 53 51



housing@cardiovascularcelltherapy.com

info@cardiovascularcelltherapy.com


7. WEB SITE AND EDUCATIONAL PRODUCTS
The website www.cardiovascularcelltherapy.com is a virtual place which contains all the information related to this Symposium and its previous editions

It is possible through this web-site to access the scientific program, to register and to reserve accommodation.



It is also a priority for this web site to offer updated information about Stem Cell Therapy for Cardiovascular Diseases, so that appropriate access to the related sites has been created. High quality educational material such as access to web casts, conferences, or updated bibliography is also accessible through this web site




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